Nephrotic and nephritic syndrome renal pathology by dr. It is my understanding that due to the albumin loss. People with nephritic syndrome tend to have high blood pressure, so a doctor will. This is a little misleading in that the bm is not made of mesangial cells, but rather there is a thickening of the bm from ic deposits and a splitting of the bm from the proliferation of mesangial cells. Nephrotic syndrome with a nephritic component associated with. Edema may also be present, although it is not nearly as severe as in nephrotic syndrome. However, there are differences between nephrotic syndrome and nephritic syndrome in the clinical features. Nephrotic vs nephritic syndrome faculty of medicine. At first, structure of glomerulus along with mechanism of glomerular injury and disease is emphasized. Jul 18, 2019 again, this is a term describing a set of symptoms and not a pathological condition in itself.
Najeeb lectures worlds most popular medical lectures. Watch our free medical lectures on basic medical sciences and clinical medicine by dr. Mar 23, 2017 and, this was pretty much about nephritic syndrome. Nephritic syndrome is also known as glomerulonephritis and it is characterized by edema, increased blood pressure and haematuria red blood cells in urine. She begins explaining when it is appropriate to consider glomerular diseases in the differential diagnosis and finishes by discusses the definition, workup, and management of both nephrotic and nephritic syndromes. If moderate glomerular injury, it will cause nonselective proteinuria without generalized edemas, lipiduria and hyperlipidemia. Minimal change disease is the third most common primary kidney disease in adults with unexplained nephrotic syndrome 10% to 15%. Nephritic syndrome is characterized by glomerular damage leading to hematuria, pyuria, water retention, and subsequent hypertension and edema. Read our list of emergency drugs used in casualty wards.
Nephritic syndrome is characterized by hematuria and pyuria, often with the presence of erythrocyte casts within the urine. Najeeb lectures acute kidney injury acute renal failure explained clearly bun creatinine ratio duration. Nephritic syndrome can present with oliguria, hypertension, and hematuria colacolored urine. Nonetheless, age should not be the only factor in defining the etiology of nephritic.
Age plays an important role in identifying the cause of nephritic syndrome. There is alsoproteinuria, hypertension, uraemia, and possibly oliguria. On a superficial level, it is safe to say that nephritic syndrome is characterized by a loss of blood in the urine from the damaged renal epithelia, whereas in nephrotic syndrome, loss of proteins is very common in the urine analysis. Causes of nephritic syndrome include postinfectious glomerulonephritis, iga nephropathy berger disease, thin basement membrane disease, and rapidly progressive glomerulonephritis. Laboratory findings include hematuria, proteinuria and creatinine, and red cell casts in urine. The many different causes of glomerular disease can be generally classified into one of three major syndromes.
However, there may be considerable overlap in their clinical presentation with some diseases presenting with components of both syndromes. Difference between nephrotic and nephritic syndrome compare. Examination of renal tissue obtained on biopsy shows a diffuse proliferative glomerulonephritis with electrondense deposits along the glomerular basement membrane. Glomerulonephritis is discussed in more detail in the separate glomerulonephritis. Hi all, so some of the defining characteristics of nephritic syndrome include oliguria, azotemia, hematuria, and hypertension. We herein report a teenager with iga nephropathy, the nephrotic syndrome and segmental glomerular scars who after developing complications from high dose corticosteroid therapy was successfully treated with tacrolimus and low dose prednisone. Nephritic and nephrotic syndrome flashcards quizlet. Acute nephritic syndrome is characterized by a sudden onset of macroscopic hematuria accompanied by hypertension, oliguria, edema, and varying degrees of renal insufficiency due to acute glomerular injury. As i have already told you that there is a lot of loss of blood in the nephritic syndrome while in nephrotic syndrome, there is loss of proteins and this is the most basic difference between the two. Nephritic syndrome is defined by hematuria, variable degrees of proteinuria, usually dysmorphic red blood cells rbcs, and often rbc casts on microscopic examination of urinary sediment. Steroids have been used widely since the early 1970s for the treatment of adult.
The upcoming article will clear out difference via a table, differential diagnosis of the two syndromes and how to interpret reports to find out which one is. Nephrotic syndrome is a rare presentation of iga nephropathy. Reducing medications, reversing my asthma and taking my. Nephrotic syndrome is a rare manifestation of iga nephropathy. A 43yearold woman with systemic lupus erythematosus has nephrotic syndrome.
Nephritic syndrome is a disease of kidney structure element glomeruli. It often occurs in glomerulonephritis, which is characterized by a thin glomerular basement membrane and small pores in the podocytes of the glomerulus, large enough to permit proteins and red blood cells to pass into the urine yielding proteinuria and hematuria. Child with clinical features of acute glomerulonephritis. In nephritic syndrome, there is some proteinuria and edema, but its not nearly as severe as in nephrotic syndrome. These syndromes are characterized by a dysfunction of normal kidney activities, hence the symptoms usually overlap. The nephritic syndrome is associated with hematuria and proteinuria and. In contrast to nephrotic syndrome, proteinuria and generalized edema are less pronounced or nonexistent in those with nephritic syndrome. The upcoming article will clear out difference via a table, differential diagnosis of the two syndromes and how to interpret reports to find out which one is nephrotic or nephritic. Najeeb videos difference between nephrotic and nephritic syndrome nephrotic syndrome is more of protein proteinuria loss while the nephritic syndrome is more of blood loss hematuria.
Nephrotic vs nephritic syndrome nephrotic and nephritic syndromes are common childhood conditions presenting with oedema and proteinuria. Master renal pathology with crystal clear concepts. Najeeb lectures are the worlds most popular medical lectures. Ns is one of the most common contributors of chronic kidney disease ckd and responsible for 12% of kidney failure in adults and 20% in children. Sep 30, 2012 nephrotic syndrome presents clinically with massive proteinuria and hypoalbuminemia, accompanied by variable forms of edema, hyperlipidemia, and lipiduria, all as a result of increased glomerular permeability 1, and it can be associated with nephritic syndrome when some or all of its clinical concomitant manifestations arterial hypertension. Nephrotic syndrome is a condition involving the loss of significant volumes of protein via the kidneys proteinuria which results in hypoalbuminaemia. Nephritic syndrome is a syndrome comprising signs of nephritis, which is kidney disease. Jun 10, 2009 in nephritic syndrome, there is some proteinuria and edema, but its not nearly as severe as in nephrotic syndrome. Hypertension in nephritic vs nephrotic syndrome student. Nov 09, 2017 the classical nephritic syndrome has a sudden onset days weeks and the main cause is post streptococcal glomerulonephritis. The list is made according to india with detailed drug class and uses. Nephrotic syndrome may affect adults and children of both sexes and of any race.
Nephrotic syndrome is just a clinical face of glomerular injury. Show description show tags show categories for webmasters. Say goodbye to high blood pressure, cholesterol and. Nephrotic syndrome may appear as a primary idiopathic renal disease or occur in association with any of a number of systemic conditions and hereditary diseases. Approximately onethird of patients with both type 1 and type 2 diabetes mellitus of at least a 25year duration will develop nephrotic syndrome, predictably leading to renal failure. Feb 16, 2009 also i think it is misleading to assoc.
Nephrotic syndrome versus nephritic syndrome current. Nov 07, 20 nephrotic vs nephritic syndrome nephrotic and nephritic syndromes are common childhood conditions presenting with oedema and proteinuria. Nephritic syndrome an overview sciencedirect topics. There are many conditions that may cause nephritic syndrome, and it can. Comprehensive medical lectures of the utmost quality across all preclinical and many clinical topics. Master of surgery doctor of medicine doctor of osteopathic medicine md. Nephritic syndrome is a syndrome comprising signs of nephritis, which is kidney disease involving inflammation. Find the life saving drugs in cardiology, respiratory, git, obstetrics, painkillers, allergy, cns and antibiotics. Nephrotic syndrome is a condition where the kidneys leak protein from the blood into the urine. Nephritic syndrome knowledge for medical students and. Kausar hamiduzzaman presents nephritic and nephrotic syndrome. Nephrotic syndrome poc nephritic syndrome edema hypoalbuminemia proteinuria hypercholesterolemia not essential characteristic htn mild edema oliguria azotemia high jvp dark urine any inflammation cause proteinuria then edema then hypovolemia then more hypoalbuminemia and hyperlipidemia mechanism 2 immunological disorder causing thickening.
The diagnostic approach to nephritic syndrome includes evaluating the patient for any suspected underlying pathology that could cause a nephritic syndrome. She begins explaining when it is appropriate to consider glomerular diseases in the differential diagnosis and finishes by discusses the definition, workup, and management of both nephrotic and nephritic sy. The clinical presentation of lupus nephritis is highly variable, ranging from asymptomatic hematuria and or proteinuria to frank nephritic syndrome to rapidly progressive glomerulonephritis with loss of renal function. Regardless of origin, the basic condition is characterized by hematuria, mild non nephrotic, ie less than 3. Nephrotic syndrome ns 1 nephrotic syndrome ns 2 definition ns is an accumulation of symptoms and signs and is characterized by proteinuria, hypoproteinemia, edema, and hyperlipidemia. Fantastic for deepening ones understanding for clinical practice and licensingboard examinations. This video will explain further on the two syndromes of kidney. Study flashcards on glomerulopathy and glomerulonephritis at. These conditions are called nephrotic and nephritic syndrome. The definition of nephrotic syndrome includes both massive proteinuria. Ppt nephrotic syndrome ns powerpoint presentation free.
Jan 23, 2015 no, its the nephrotic presentation of a disease which usually presents as a nephritic syndrome. Although primary ns is a relatively rare condition, anyone can get it. Difference between nephrotic and nephritic syndrome. Overview of nephritic syndrome msd manual professional edition. Nephrotic syndrome nephritic syndrome is characterized by inflammation of the glomeruli glomerulonephritis and renal dysfunction. The best sleeping position for back pain, neck pain, and sciatica tips from a physical therapist duration. If the person in the office is being examined by a physician, some physical exam findings consistent with nephritic syndrome include the following. Difference between nephrotic syndrome and nephritic. Glomerulonephritis can present with different clinical syndromes. Najeeb lectures medical lectures videos if you found this helpful then share. Nephritic syndrome, like nephrotic syndrome, may involve low level of. Difference between nephrotic syndrome and nephritic syndrome.
Glomerulonephritis principles, nephrotic syndrome, nephritic syndrome. The thing with nephritic syndrome is that the lesions causing it all have increased cellularity within the glomeruli, accompanied by a leukocytic infiltrate hence the suffix itic. This lesson will discuss two syndromes associated with diseases that affect the filters inside of the kidneys, the glomeruli. It can be caused by a variety of conditions including autoimmune, hereditary, and infectious diseases. In the united states, diabetes mellitus is the most common cause of nephrotic syndrome. Nephrotic syndrome is more of protein proteinuria loss while the nephritic syndrome is more of blood loss hematuria. Quizlet flashcards, activities and games help you improve your grades. Again, this is a term describing a set of symptoms and not a pathological condition in itself.
Both fa and pathoma mention hypertension being a feature in nephritic syndrome due to an inability to excrete saltsalt retention. The thing with nephritic syndrome is that the lesions causing it all have increased cellularity within the glomeruli, accompanied by a. Later the patient developed ht and renal dysfunction, and will fall in the syndromic diagnosis of nephritic syndrome the whole exercise of this case was to tell you that the classification of glomerular disease is not perfect. The degree of proteinuria in iga nephropathy predicts poor prognosis. Overview of nephritic syndrome genitourinary disorders. Patients also display hypertension, azotemia, and oliguria. Haematuria can be frank haematuria or microscopic oedema to a lesser extent compared to nephrotic syndrome reduced. Nephritic syndrome definition of nephritic syndrome by. Nephrotic syndrome poc nephritic syndrome edema hypoalbuminemia proteinuria hypercholesterolemia not essential characteristic htn mild edema oliguria azotemia high jvp dark urine any inflammation cause proteinuria then edema then hypovolemia then more hypoalbuminemia and hyperlipidemia mechanism 2 immunological disorder. In children under age 5 years the disease usually takes the form of idiopathic. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
Learn about nephrotic syndrome leaky kidneys and the dangers of nephrotic. Due to slightest glomerular injury, the clinical picture will be selective proteinuria. Nephrotic syndrome, nephritic syndrome, and asymptomatic renal disease. Huikim yap, perry yewweng lau, in comprehensive pediatric nephrology, 2008. Nephrotic syndrome diagnosis and treatment mayo clinic. The main difference between this and nephrotic syndrome is that in nephritic syndrome haematuria is present. What are the 4 main symptoms of nephrotic syndrome. The most common cause is immunoglobulin a iga nephropathy, also known as bergers disease, but other causes include postinfectious glomerulonephritis and lupus nephritis.
1014 39 1272 1461 1348 113 231 833 1574 677 415 836 768 1342 453 799 924 1146 1460 3 1451 1028 705 822 579 1172 1274 548 1391 413 943 1457 68 1396 555 665 325